Akhilesh kumar Kuril | Biochemistry | Research Excellence Award

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Mr. Akhilesh kumar Kuril | Biochemistry | Research Excellence Award

Bhagwant university, Ajmer, India

Author Profile

🎓 Early Academic Pursuits

Akhilesh Kumar Kuril’s journey into the world of pharmaceutical sciences began with a strong academic foundation. Born on June 8, 1986, in India, Akhilesh demonstrated a keen interest in chemistry and pharmaceutical sciences early in life. His academic pursuit started with a Bachelor of Pharmacy (B. Pharm) from Ram-Eesh Institute of Vocational & Technical Education in Greater Noida, Uttar Pradesh. This institution is affiliated with the Abdul Kalam Technical University, formerly Uttar Pradesh Technical University (UPTU), Lucknow. Akhilesh completed his B. Pharm between 2005 and 2009, securing an impressive 71.0% marks. This early success laid the groundwork for his future achievements in pharmaceutical chemistry.He continued his academic journey by pursuing a Master of Pharmacy (M. Pharm) in Pharmaceutical Chemistry from Babu Banarasi Das National Institute of Technology & Management, Lucknow. This institution, also affiliated with Abdul Kalam Technical University, provided him with the platform to delve deeper into pharmaceutical sciences. Between 2009 and 2011, Akhilesh excelled in his M. Pharm studies, achieving 76.0% marks. His dedication and hard work during these formative years were evident, and they set the stage for his future contributions to the field.

💼 Professional Endeavors

Akhilesh’s professional career is marked by his extensive experience as an analytical scientist. With over 12 years of experience in the analytical research and development of drug substances, both small and large molecules, and drug products such as peptides, proteins, injectables, ophthalmic, and oral solid dosage forms, Akhilesh has established himself as a key figure in the pharmaceutical industry. Currently, he holds the position of Chemist II, QC at Ambiopharm Inc., located in North Augusta, South Carolina, USA.In his role, Akhilesh is responsible for the characterization study and developmental studies for drug product analytical method validation and troubleshooting. His expertise in responding to deficiencies received from regulatory agencies highlights his critical role in ensuring that pharmaceutical products meet stringent regulatory standards. Akhilesh’s proficiency in various analytical techniques, including chromatographic techniques such as Reverse Phase (RP), Ion Pair (IP), Ion Exchange Chromatography (IEX), and Size Exclusion Chromatography (SEC), coupled with different detectors like UV, RI, Fluorescence, MALS, and MS, underscores his technical prowess.

🔬 Contributions and Research Focus

Akhilesh’s contributions to the field of pharmaceutical analysis are substantial. His research focus extends to peptide characterization techniques, including Circular Dichroism, Fluorescence Spectrometry, UHPLC-HRMS (Top-down and Bottom-up MS), Dynamic Light Scattering (DLS), SV-AUC, and CE. Additionally, he is well-versed in solid-state characterization techniques such as Particle Size Analysis, PXRD, DSC, and TGA. These techniques are critical in ensuring the quality, efficacy, and safety of pharmaceutical products.His work in method development, validation, and regular analysis using high-performance instruments like HPLC, UPLC, and UHPLC-HRMS has been instrumental in advancing the field of pharmaceutical analysis. Akhilesh’s ability to apply bioinformatics tools for protein mapping and amino acid sequencing further enhances the precision and reliability of his research.

🏆 Accolades and Recognition

Akhilesh’s dedication to excellence in his field is reflected in the numerous certifications and recognitions he has received. In August 2021, he earned Green Belt and Black Belt Certifications in Lean Six Sigma with a Seal of Excellence from Exemplar Global and Benchmark Six Sigma. These certifications demonstrate his commitment to continuous improvement and operational excellence. In September 2021, he furthered his credentials by receiving a Certificate in Excellence in Continuous Improvement Leadership (ECIL) from Benchmark Six Sigma.These accolades not only recognize Akhilesh’s expertise in pharmaceutical analysis but also highlight his leadership abilities in driving efficiency and quality in pharmaceutical research and development.

🌍 Impact and Influence

Akhilesh’s impact on the pharmaceutical industry is profound. His work at Ambiopharm Inc. and previous roles has contributed significantly to the development and validation of methods that ensure the safety and efficacy of pharmaceutical products. His expertise in handling complex regulatory challenges and his ability to troubleshoot analytical methods have made him a valuable asset to his organization and the industry at large.Moreover, Akhilesh’s research in peptide and protein characterization techniques has influenced the way these essential biomolecules are analyzed, leading to more accurate and reliable results. His contributions are particularly important in the context of developing generic peptide products, where precise characterization is critical to ensuring bioequivalence and safety.

👨‍💻 Legacy and Future Contributions

Looking ahead, Akhilesh Kumar Kuril’s legacy in the pharmaceutical industry is poised to grow even further. As he continues to pursue his Ph.D. in Pharmaceutical Analysis from Bhagwant University, Rajasthan, India, Akhilesh is on track to make even more significant contributions to the field. With his thesis already submitted and his graduation anticipated in 2024, Akhilesh’s research and findings are expected to add valuable knowledge to the field of pharmaceutical analysis.Akhilesh’s future contributions will likely focus on advancing analytical techniques and developing innovative methods for drug substance and product characterization. His ongoing commitment to excellence, continuous improvement, and innovation ensures that he will remain at the forefront of the pharmaceutical industry, driving advancements that benefit both the industry and patients worldwide.

Notable Publications 

  • Title: Analytical considerations for characterization of generic peptide product: A regulatory insight
    Authors: Kuril, A.K., Saravanan, K., Subbappa, P.K.
    Journal: Analytical Biochemistry
    Year: 2024.
  • Title: High-throughput method for Peptide mapping and Amino acid sequencing for Calcitonin Salmon in Calcitonin Salmon injection using Ultra High Performance Liquid Chromatography – High Resolution Mass Spectrometry (UHPLC-HRMS) with the application of Bioinformatic tools
    Authors: Kuril, A.K., Saravanan, K.
    Journal: Journal of Pharmaceutical and Biomedical Analysis
    Year: 2024.
  • Title: A comprehensive guide for secondary structure and tertiary structure determination in peptides and proteins by circular dichroism spectrometer
    Authors: Kuril, A.K., Vashi, A., Subbappa, P.K.
    Journal: Journal of Peptide Science
    Year: 2024.

OWAIS BHAT | Biochemistry | Best Researcher Award

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Assist Prof Dr. OWAIS BHAT | Biochemistry | Best Researcher Award

Central University of Kashmir- India

Author Profile

🧑‍🎓Early Academic Pursuits 

Dr. Owais Mohmad Bhat, M.Sc., Ph.D., began his illustrious academic journey in the picturesque region of Kashmir, India. His passion for life sciences led him to pursue a B.Sc. in Biochemistry, Chemistry, and Zoology from Sri Pratap College, affiliated with the University of Kashmir. During this period, he developed a strong foundation in the biological sciences, which would later be crucial in his research pursuits.Following his undergraduate studies, Dr. Bhat continued his academic journey at the University of Kashmir, where he completed his M.Sc. in Biochemistry from 2005 to 2007. This period was marked by his growing interest in molecular biology and biochemistry, particularly in understanding the biochemical mechanisms underlying various physiological and pathological processes.His academic pursuits eventually led him to one of the most prestigious institutions in India, the Postgraduate Institute of Medical Education and Research (PGIMER) in Chandigarh. Here, Dr. Bhat embarked on his Ph.D. journey in Biochemistry under the guidance of eminent professors, including Prof. Veena Dhawan, Prof. Deepak Kaul, and Dr. N.V. Giridharan. His thesis, titled “To Study the Effect of Terminalia Arjuna on Interleukin-18 Induced Modulation of Peroxisome Proliferator Activated Receptor-γ Transcriptome in Apo E -/- Mice Model of Atherosclerosis,” explored the molecular mechanisms involved in cardiovascular diseases, particularly atherosclerosis, and the potential therapeutic effects of natural compounds.

🧪Professional Endeavors and Research Focus

Dr. Owais Mohmad Bhat’s professional journey is characterized by his dedication to understanding complex biochemical pathways and their implications in human health and disease. After completing his Ph.D., he moved to the United States, where he worked as a Post-Doctoral Researcher in the Department of Comparative Biomedical Sciences at Louisiana State University. Under the mentorship of Professor Yogesh Saini, Dr. Bhat’s research focused on the role of macrophages in respiratory diseases, particularly the impact of altered macrophage populations on immune responses in respiratory airspaces.In 2016, Dr. Bhat joined the Department of Pharmacology and Toxicology at Virginia Commonwealth University as a Post-Doctoral Researcher. Here, he worked under the supervision of Professor Pin-Lan Li, where he delved into the regulation of autophagic flux by lysosome-associated signaling pathways. His research uncovered critical insights into how deficient autophagy in coronary arterial smooth muscle cells (CASMCs) could lead to atherosclerosis, with a particular focus on the role of lysosomal dysfunction in vascular calcification.ince December 2021, Dr. Bhat has been serving as a Scientist-D and Ramalingaswami Fellow at the Department of Biotechnology, School of Life Sciences, Central University of Kashmir. His current research focuses on vascular calcification, particularly the formation and accumulation of calcium phosphate salts within the vascular wall, which is associated with aging, chronic kidney disease, diabetes mellitus, and atherosclerosis. His work explores the role of small membrane-bound bodies, known as matrix vesicles (MVs), and their exosome counterparts in nucleating calcium phosphate crystals, leading to vascular calcification.

🧬Contributions and Research Focus

Dr. Bhat’s research has significantly contributed to our understanding of the molecular mechanisms underlying vascular calcification. His work has demonstrated how lysosomal dysfunction and sphingolipid metabolism play a crucial role in the excretion of exosomes from arterial smooth muscle cells (SMCs), ultimately leading to vascular calcification. His research also highlights the potential therapeutic targets within the mammalian target of rapamycin complex (mTORC) signaling pathways, which could be manipulated to prevent or reverse vascular calcification.In addition to his research on vascular calcification, Dr. Bhat has also contributed to the field of cardiovascular diseases through his studies on the role of sphingolipids, ceramide, and sphingosine-1-phosphate (S1P) in regulating autophagy and exosome secretion. His research has opened new avenues for understanding how these molecules influence the development of calcification in atherosclerotic plaques and arterial walls.

🏆Accolades and Recognition

Dr. Owais Mohmad Bhat’s dedication to his research has not gone unnoticed. He has been awarded the prestigious Ramalingaswami Fellowship by the Department of Biotechnology, Government of India, which recognizes outstanding scientists returning to India to contribute to the country’s scientific research landscape. This fellowship has allowed Dr. Bhat to continue his groundbreaking research at the Central University of Kashmir, where he has secured funding of 113.6 Lakhs for his projects.

🌍Impact and Influence

Dr. Bhat’s work has had a profound impact on the scientific community’s understanding of vascular calcification and its underlying mechanisms. His research has provided valuable insights into potential therapeutic targets for preventing or treating cardiovascular diseases, particularly in populations at high risk, such as those with chronic kidney disease or diabetes.Moreover, as a mentor to four Ph.D. scholars, Dr. Bhat is actively contributing to the next generation of scientists. His guidance and expertise are helping shape the future of biochemistry and molecular biology research in India.

🌟Legacy and Future Contributions

Dr. Owais Mohmad Bhat’s research legacy is one of dedication to unraveling the complexities of human health and disease at the molecular level. His work on vascular calcification and the role of sphingolipids in cardiovascular diseases is paving the way for new therapeutic approaches that could significantly impact public health.As he continues his research at the Central University of Kashmir, Dr. Bhat is poised to make even more significant contributions to the field. His future work is expected to delve deeper into the molecular mechanisms of vascular calcification, potentially leading to new treatments that could prevent the progression of atherosclerosis and other related diseases.In summary, Dr. Owais Mohmad Bhat, M.Sc., Ph.D., is a distinguished scientist whose work is making a lasting impact on the field of biochemistry and molecular biology. His research, mentorship, and dedication to advancing scientific knowledge are contributing to a brighter future for cardiovascular disease treatment and prevention.

Citations

A total of 751 citations for his publications, demonstrating the impact and recognition of his research within the academic community.

  • Citations         751
  • h-index           35
  • i10-index        17

Notable Publications 

  • Title: Contribution of Hepatic Steatosis–Intensified Extracellular Vesicle Release to Aggravated Inflammatory Endothelial Injury in Liver-Specific Asah1 Gene Knockout Mice
    Authors: Yuan, X., Bhat, O.M., Zou, Y., Zhang, Y., Li, P.-L.
    Journal: American Journal of Pathology
    Year: 2023
  • Title: A Review on Anti-Nutritional Factors: Unraveling the Natural Gateways to Human Health
    Authors: Salim, R., Nehvi, I.B., Mir, R.A., Ali, S., Bhat, O.M.
    Journal: Frontiers in Nutrition
    Year: 2023
  • Title: Endothelial Acid Sphingomyelinase Promotes NLRP3 Inflammasome and Neointima Formation during Hypercholesterolemia
    Authors: Yuan, X., Bhat, O.M., Zou, Y., Zhang, Y., Li, P.-L.
    Journal: Journal of Lipid Research
    Year: 2022
  • Title: Impairment of Ceramide-Mediated Endothelial Instant Membrane Resealing During Diabetes Mellitus
    Authors: Chen, Y., Li, G., Bhat, O.M., Zhang, Y., Li, P.-L.
    Journal: Frontiers in Physiology
    Year: 2022
  • Title: Exosome Biogenesis and Lysosome Function Determine Podocyte Exosome Release and Glomerular Inflammatory Response during Hyperhomocysteinemia
    Authors: Huang, D., Li, G., Bhat, O.M., Ritter, J.K., Li, P.-L.
    Journal: American Journal of Pathology
    Year: 2022.

Md Azaharuddin | Biochemistry | Best Researcher Award

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Mr .Md Azaharuddin | Biochemistry | Best Researcher Award

University of Kalyani- India

Author Profile

Early Academic Pursuits

Md Azaharuddin began his academic journey with a strong foundation in Botany, graduating with distinction from Jiaganj Sripat Singh College under the University of Kalyani in 2016. His passion for botanical sciences led him to pursue a Master’s degree in Botany from the Department of Botany, University of Kalyani, where he graduated in 2018. Building on his expertise, Azaharuddin embarked on his Ph.D. journey in Biochemistry at the Department of Biochemistry & Biophysics, University of Kalyani, demonstrating exceptional academic performance with an impressive coursework score of 81.25% in 2020.

Professional Endeavors

Currently serving as a Senior Research Fellow (SRF) at the Department of Biochemistry and Biophysics, University of Kalyani, Md Azaharuddin brings over 4 years of dedicated research experience. Under the joint guidance of Dr. Rakhi Dasgupta and Prof. Tarakdas Basu, he specializes in the study of Heat Shock Proteins (HSPs) within bacterial systems. His research spans proteomics, stress biochemistry, chaperone systems, and molecular biology, focusing on elucidating the roles and functions of HSPs in cellular stress responses.

Contributions and Research Focus

Azaharuddin’s research contributions are marked by his keen exploration of Heat Shock Proteins, particularly their oligomeric polydispersity and chaperone activities in Escherichia coli. His notable publications include a comprehensive review titled “A review on oligomeric polydispersity and oligomers-dependent holding chaperone activity of the small heat-shock protein IbpB of Escherichia coli,” published in Cell Stress and Chaperones. This work has significantly contributed to understanding how these proteins facilitate cellular adaptation under stress conditions.

Accolades and Recognition

Md Azaharuddin’s academic achievements have been acknowledged through various accolades, including his exceptional performance in the GATE 2019 examination, where he secured a score of 367 conducted by IIT-Madras. Additionally, he successfully cleared the 22nd State Eligibility Test (SET) in 2020 conducted by the West Bengal College Service Commission, further affirming his expertise and qualification in biochemistry.

Impact and Influence

Azaharuddin’s research is poised to make a profound impact on the field of molecular biology and biochemistry, particularly in enhancing our understanding of cellular stress responses mediated by Heat Shock Proteins. His work not only contributes to fundamental research but also holds potential applications in biotechnology, agriculture, and medicine, where stress tolerance mechanisms are crucial for improving crop yield and developing therapeutic interventions.

Legacy and Future Contributions

Looking ahead, Md Azaharuddin aims to continue advancing his research on Heat Shock Proteins, with a focus on unraveling novel aspects of their structure-function relationships and their applications in biotechnological innovations. His dedication to scientific inquiry and his proactive approach to tackling complex biological questions position him as a promising scientist poised to leave a lasting legacy in the realm of molecular biology.In conclusion, Md Azaharuddin’s academic journey and research achievements underscore his commitment to advancing scientific knowledge, particularly in the intricate mechanisms of cellular stress responses. With a robust foundation in botany and biochemistry, coupled with his research acumen and scholarly contributions, Azaharuddin continues to shape the future of microbiological research through his innovative pursuits and dedication to scientific excellence.