Early Academic Pursuits

His journey into the realm of pharmaceutical research began with a strong foundation in chemistry. Graduating with honors in Chemistry, Physics, and Mathematics from the University of Burdwan, India, he exhibited exceptional academic prowess. His passion for organic chemistry led him to pursue a Master's degree with a specialization in Organic Chemistry from the University of Calcutta. Subsequently, he delved deeper into the field by obtaining his Ph.D. in Biochemistry from CSIR-Indian Institute of Chemical Biology/University of Calcutta. During his academic pursuits, he developed a keen interest in natural product chemistry, cancer chemoprevention, and translational research.

Professional Endeavors

His professional journey in pharmaceutical research spans over a decade, during which he has made significant contributions to the field. His post-doctoral experience at CSIR-Indian Institute of Chemical Biology and the University of Pittsburgh provided him with invaluable exposure to natural product research, cancer chemoprevention, and translational studies. Subsequently, he continued his research endeavors as a Scientist at IASST, Guwahati, where he focused on metabolic disorders and translational research. His expertise and dedication earned him recognition as a Senior Research Associate and Senior Research Fellow under the prestigious Scientist Pool's Scheme and CSIR, respectively.

Contributions and Research Focus in Drug Development

His research focuses on chemoprevention, molecular pharmacology, signal cross-talk, system biology, and translational research. His notable contributions include elucidating the mechanisms of action of natural compounds like Ajoene and Withaferin A in breast cancer treatment. Through rigorous in vitro and in vivo studies, he demonstrated the efficacy of Withaferin A in inhibiting breast cancer progression, irrespective of the cancer subtype. Additionally, his research shed light on the role of PIN1 protein in breast cancer progression and the inhibitory effects of Withaferin A on PIN1, offering novel therapeutic avenues for cancer treatment. Currently, he is exploring the therapeutic potential of combining the dietary phytochemical Mahanine with conventional medications for breast cancer treatment, further advancing the field of translational research.

Accolades and Recognition

His outstanding contributions to pharmaceutical research have earned him several accolades and awards. His notable achievements include being awarded as a Senior Research Associate and Senior Research Fellow by CSIR. Additionally, his research findings have been published in prestigious journals like the Journal of the National Cancer Institute, garnering recognition and acclaim from the scientific community.

Impact and Influence

His therapeutic targets, he has contributed significantly to the field of medicinal chemistry and pharmacology. His findings have the potential to revolutionize cancer treatment strategies and improve patient outcomes worldwide.

Legacy and Future Contributions

Notable Publications

• Apoptotic effects of mahanine on human leukemic cells are mediated through crosstalk between Apo-1/Fas signaling and the Bid protein and via mitochondrial pathways
• Oxidative inhibition of Hsp90 disrupts the super‐chaperone complex and attenuates pancreatic adenocarcinoma in vitro and in vivo
• Improved chemosensitivity in cervical cancer to cisplatin: synergistic activity of mahanine through STAT3 inhibition
• Mahanine, a novel mitochondrial complex-III inhibitor induces G0/G1 arrest through redox alteration-mediated DNA damage response and regresses glioblastoma multiforme
• Ricinus communis L. fruit extract inhibits migration/invasion, induces apoptosis in breast cancer cells and arrests tumor progression in vivo
• Phytochemical portfolio and anticancer activity of Murraya koenigii and its primary active component, mahanine
• Mahanine synergistically enhances cytotoxicity of 5-fluorouracil through ROS-mediated activation of PTEN and p53/p73 in colon carcinoma
• Mahanine, a DNA minor groove binding agent exerts cellular cytotoxicity with involvement of C-7-OH and− NH functional groups
• Mitochondrial dysfunction in cancer chemoprevention by phytochemicals from dietary and medicinal plants
• Withaferin A-mediated apoptosis in breast cancer cells is associated with alterations in mitochondrial dynamics